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| ABOITIZ,FRANCISCO. |
| Although homology is central to evolutionary interpretations, establishing it has become a highly disputed issue in some instances. Here I argüe for a developmental understanding of evolution, where modifications of the developmental programs are a key source of evolutionary novelty. Although this perspective is not new, in comparative neurobiology it has remained controversial. Specifically, the evolutionary origin of the mammalian neocortex has been a particularly debated point. I propose a perspective that could help reconcile a long standing controversy: either the mammalian neocortex corresponds as a whole to the dorsal hemisphere of reptiles and birds, or alternatively its lateral aspect corresponds to the lateral cerebral hemisphere and is partly... |
| Tipo: Journal article |
Palavras-chave: Dorsal ventricular ridge; Neocortex; Pallium; Subventricular zone; Ventricular zone. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2010000400002 |
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| Martin, Corinne; Vaz, Sandrine; Koubbi, Philippe; Meaden, Geoff; Engelhard, Georg H.; Lauria, Valentina; Gardel, Laure; Coppin, Franck; Delavenne, Juliette; Dupuis, Ludovic; Ernande, Bruno; Foveau, Aurelie; Lelievre, Stephanie; Morin, Jocelyne; Warembourg, Caroline; Carpentier, Andre. |
| The eastern English Channel, which connects the Atlantic Ocean to the North Sea through the Dover Strait, is an area where numerous and often conflicting human activities take place. A cross-border multidisciplinary project called CHARM was initiated to provide knowledge and tools for planners and decision-makers to durably manage the shared marine living resources. One such tool was an atlas of fish spatial distributions and modelled habitats, which was used here to investigate ontogenic and seasonal shifts in fish spatial distribution and habitat through a case-study, the dab Limanda limanda. Survey data for several life-history stages (eggs, larvae, coastal nurseries, < and > 1 year old) and seasons were used to map spatial patterns (using... |
| Tipo: Text |
Palavras-chave: Pleuronectidae; Limanda limanda; Eastern Channel; Spatial distribution; Modelling; Kriging; Ichthyoplankton; Trawl; CUFES. |
| Ano: 2010 |
URL: http://archimer.ifremer.fr/doc/00008/11942/8646.pdf |
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| Massuquetti,Angélica. |
| Este artigo investiga o processo de modernização agrícola na França com base na interpretação de economistas, sociólogos e cientistas políticos, envolvendo especialmente o debate da economia e da sociologia rural contemporâneas. O objetivo é compreender a sua dinâmica pelo cruzamento entre diferentes áreas do conhecimento, visando refletir acerca de um modelo interpretativo para a análise da especificidade do processo brasileiro de modernização agrícola. O mundo rural não se transformou unicamente no âmbito econômico, por meio da adoção de inovações e de novas inserções no mercado, mas houve também a construção de novas identidades políticas e sociais no campo. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Modernização; Agricultura; Identidade social. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-20032010000200004 |
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| Steven J. Koch; Lawrence J. Herskowitz. |
| Kinesin-1 is a homodimeric molecular motor protein that uses ATP and a hand-over-hand motion to transport cargo along microtubules. How kinesin converts chemical energy into directed motion is a question that has been actively studied since its discovery. Even at the most coarse-grained level of chemical kinetics, understanding is still lacking. Minimal kinetic models are often developed to both explain kinesin’s hand-over-hand forward-stepping behavior and to infer important kinetic rate constants from experimental data. These minimal models are often limited to a handful of two-headed states on a core cycle and have been essential for the current level of understanding. However, it is not always clear how to evolve these core-cycle models to... |
| Tipo: Manuscript |
Palavras-chave: Molecular Cell Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5038/version/1 |
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| Wu,Y.; Han,W.; Liu,G.-N.. |
| We have demonstrated that a synthetic DNA enzyme targeting early growth response factor-1 (Egr-1) can inhibit neointimal hyperplasia following vascular injury. However, the detailed mechanism of this inhibition is not known. Thus, the objective of the present study was to further investigate potential inhibitory mechanisms. Catalytic DNA (ED5) and scrambled control DNA enzyme (ED5SCR) were synthesized and transfected into primary cultures of rat vascular smooth muscle cells (VSMCs). VSMC proliferation and DNA synthesis were analyzed by the MTT method and BrdU staining, respectively. Egr-1, TGF-β1, p53, p21, Bax, and cyclin D1 expression was detected by RT-PCR and Western blot. Apoptosis and cell cycle assays were performed by FACS. Green fluorescence could... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DNA enzyme; Egr-1; VSMC; Proliferation; Apoptosis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100004 |
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| Flores,Carlos I.; Holzapfel,Eduardo A.; Lagos,Octavio. |
| An online dynamic decision support system (DDSS) was developed, to support the farm water management in surface irrigation. The online DDSS was based on the formulation and integration of three components: a dynamic-relational data base, an administrator model, and a graphical user interface. The DDSS allows routines of actualization, edition and addition of online data, providing information in real time. The online DDSS was applied in an orange orchard (Citrus sinensis L. Osbeck) cv. Valencia Late under furrow irrigation. The results pointed out that the time irrigation cutoff was the main significant management factor, to decrease the hazard of leaching, superficial runoff and percolation. Applying the results obtained with the DDSS, furrow irrigation... |
| Tipo: Journal article |
Palavras-chave: Furrow irrigation; On-line irrigation management; Orange orchard. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392010000200011 |
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| Akpalu, Wisdom. |
| This paper employs a dynamic model for crimes that involve time and punishment to analyze the use of a net with illegal mesh size in a management regime where each community claims territorial use right over a fishery but has a discount rate that may differ from the social discount rate. The equilibrium stock and harvest levels are found to be much lower if the regulation is violated. Moreover, the optimal penalty for violation must be decreasing in the shadow cost of taking the risk to fish illegally, and increasing the risk of punishment increases the equilibrium stock level. |
| Tipo: Journal Article |
Palavras-chave: Crime; Dynamic model; Fishery; Regulation; Resource /Energy Economics and Policy. |
| Ano: 2010 |
URL: http://purl.umn.edu/61059 |
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| Roberto Serra; Villani Marco; Alessia Barbieri. |
| Cell differentiation is a complex phenomenon whereby a stem cell becomes progressively more specialized and eventually gives rise to a specific cell type. Differentiation can be either stochastic or, when appropriate signals are present, it can be driven to take a specific route. Induced pluripotency has also been recently obtained by overexpressing some genes in a differentiated cell. Here we show that a stochastic dynamical model of genetic networks can satisfactorily describe all these important features of differentiation, and others. The model is based on the emergent properties of generic genetic networks, it does not refer to specific control circuits and it can therefore hold for a wide class of lineages. The model points to a peculiar role of... |
| Tipo: Manuscript |
Palavras-chave: Molecular Cell Biology; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4741/version/1 |
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